In vitro and in vivo evaluations of Mg-Zn-Gd alloy membrane on guided bone regeneration for rabbit calvarial defect

Journal of Magnesium and Alloys

Jun Shi¹  Guofang Shen¹  Hongzhou Shen²  Jiawen Si²  Hongwei Miao³  Guangyin Yuan³  Yuan Tian³  Hua Huang³ 

[1] Corresponding authors.;Department of Oral and Craniomaxillofacial Surgery, Shanghai Ninth People's Hospital, College of Stomatology, School of Medicine, Shanghai Jiao Tong University, Shanghai Key Laboratory of Stomatology, National Clinical Research Center for Oral Diseases, Shanghai, 200011, China;National Engineering Research Center of Light Alloy Net Forming and Key State Laboratory of Metal Matrix Composites, School of Materials Science and Engineering, Shanghai Jiao Tong University, Shanghai, 200240 China;

关键词: Magnesium alloy membrane;    Calcium-phosphate coating;    Antibacterial;    Biodegradable;    Guided bone regeneration;   

DOI  :  

来源: DOAJ

【 摘 要 】

To develop a biodegradable membrane with guided bone regeneration (GBR), a Mg-2.0Zn-1.0Gd alloy (wt.%, MZG) membrane with Ca-P coating was designed and fabricated in this study. The microstructure, hydrophilicity, in vitro degradation, cytotoxicity, antibacterial effect and in vivo regenerative performance for the membrane with and without Ca-P coating were evaluated. After coating, the membrane exhibited an enhance hydrophilicity and corrosion resistance, showed good in vitro cytocompatibility upon MC3T3E-1 cells, and exhibited excellent antibacterial effect against E. coli, Staphylococcus epidermis and Staphylococcus aureus, simultaneously. In vivo experiment using the rabbit calvarial defect model confirmed that Ca-P coated MZG membrane underwent progressive degradation without inflammatory reaction and significantly improved the new bone formation at both 1.5 and 3 months after the surgery. All the results strongly indicate that MZG with Ca-P coating have great potential for clinical application as GBR membranes.

【 授权许可】

Unknown