Limited association between disinfectant use and either antibiotic or disinfectant susceptibility of Escherichia coli in both poultry and pig husbandry

BMC Veterinary Research

Els Van Coillie¹  Koen De Reu¹  Helder Maertens¹  Evelyne Meyer²  Jeroen Dewulf³ 

[1] Flanders Research Institute for Agriculture, Fisheries and Food (ILVO), Technology and Food Science Unit;Veterinary Biochemistry Unit, Department of Pharmacology, Toxicology and Biochemistry, Faculty of Veterinary Medicine, Ghent University;Veterinary Epidemiology Unit, Department of Reproduction, Obstetrics and Herd Health, Faculty of Veterinary Medicine, Ghent University;

关键词: Antibiotic resistance;    Disinfectant susceptibility;    E. coli;    Broiler flocks;    Pig herds;    Biocidal products;   

DOI  :  10.1186/s12917-019-2044-0

来源: DOAJ

【 摘 要 】

Abstract Background Farm disinfectants are widely used in primary production, but questions have been raised if their use can select for antimicrobial resistance. The present study examined the use of disinfectants in poultry and pig husbandry and its contribution to the antibiotic and disinfectant susceptibility of Escherichia coli (E. coli) strains obtained after cleaning and disinfection. On those field isolates antibiotic susceptibility was monitored and susceptibility to commonly used active components of farm disinfectants (i.e. glutaraldehyde, benzalkoniumchloride, formaldehyde, and a formulation of peracetic acid and hydrogen peroxide) was tested. Results This study showed a high resistance prevalence (> 50%) for ampicillin, sulfamethoxazole, trimethoprim and tetracycline for both production animal categories, while for ciprofloxacin only a high resistance prevalence was found in broiler houses. Disinfectant susceptibility results were homogenously distributed within a very small concentration range. Furthermore, all E. coli strains were susceptible to in-use concentrations of formaldehyde, benzalkoniumchloride and a formulation of peracetic acid and hydrogen peroxide, indicating that the practical use of disinfectants did not select for disinfectant resistance. Moreover, the results showed no indications for the selection of antibiotic resistant bacteria through the use of disinfectants in agricultural environments. Conclusion Our study suggests that the proper use of disinfectants in agricultural environments does not promote antibiotic resistance nor reduce E. coli disinfectant susceptibility.

【 授权许可】

Unknown