Bulletin of the National Research Centre | |
Bacterial gastroenteritis in children below five years of age: a cross-sectional study focused on etiology and drug resistance of Escherichia coli O157, Salmonella spp., and Shigella spp. | |
Suman Das1  Asma Talukder2  Mohammad Sharif Uddin3  Md. Mijanur Rahman3  K. M. Shariful Islam4  Md. Imranul Hoq4  Md. Omar Faruk5  | |
[1] Bangladesh Council of Scientific and Industrial Research (BCSIR) Laboratories, 4220, Chattogram, Chattogram, Bangladesh;Department of Biotechnology and Genetic Engineering, Noakhali Science and Technology University, 3814, Noakhali, Bangladesh;Department of Microbiology, Noakhali Science and Technology University, 3814, Noakhali, Bangladesh;Department of Microbiology, University of Chittagong, 4331, Chattogram, Bangladesh;Department of Statistics, Noakhali Science and Technology University, 3814, Noakhali, Bangladesh; | |
关键词: Gastroenteritis; E. coli; Shigella; Salmonella; Antibiotic resistance; | |
DOI : 10.1186/s42269-021-00597-9 | |
来源: Springer | |
【 摘 要 】
BackgroundGastroenteritis is a common infectious disease in children, which results in high mortality and morbidity, especially in resource-poor countries. This study presents the selected main gastroenteritis causing bacteria, including Escherichia coli O157, Salmonella and Shigella species delineating their prevalence and resistance pattern to the clinically used antibiotics.ResultsA total of 346 stool specimens from children of clinically suspected gastroenteritis below five years have been obtained, and bacterial pathogens were recovered using selective media, biochemical and serologic tests. We found that 35 (10%) of them were confirmed bacterial gastroenteritis (BGE) with either Escherichia coli O157 (14%), Salmonella spp. (43%), and Shigella spp. (43%). Nevertheless, the prevalence of E. coli O157, Salmonella spp., and Shigella spp. in this study were documented as 1.45%, 4.34%, and 4.34%, respectively. Moreover, 2 (40%) of E. coli O157, 4 (26.67%) of Salmonella spp., and 14 (93%) of the Shigella spp. were found as multidrug-resistant. Nonetheless, Shigella spp. isolates showed 100%, 87%, and 73% resistance to cotrimoxazole, ciprofloxacin, and azithromycin respectively, while E. coli O157 showed 80% resistance to cotrimoxazole and 60% to ciprofloxacin and azithromycin. On the contrary, cotrimoxazole, ciprofloxacin, azithromycin, and tetracycline were resistant in 40%, 47%, 27%, and 53% of Salmonella spp. isolates respectively.ConclusionThese findings generate significant insights on the prevalence and antibiotic resistance of the three major gastroenteritis causing bacteria in the study area. Therefore, it will help physicians and policymakers selecting the right antibiotics in essential cases, particularly, reevaluation of recommending cotrimoxazole, ciprofloxacin, and azithromycin in the management of bacterial gastroenteritis.
【 授权许可】
CC BY
【 预 览 】
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RO202109170614627ZK.pdf | 893KB | download |