期刊论文详细信息
Molecules
Synthesis and Antimicrobial Studies of New Antibacterial Azo-Compounds Active against Staphylococcus aureus and Listeria monocytogenes
Rosita Diana1  Ugo Caruso1  Simona Concilio2  Lucia Sessa3  Stefano Piotto3  Pio Iannelli3  Gabriel Torrens4  Carlos Juan4 
[1] Department of Chemical Science, University of Napoli “Federico II”, Cupa Nuova Cintia, Napoli 21-80126 , Italy;Department of Industrial Engineering, University of Salerno, Via Giovanni Paolo II 132, 84084 Fisciano (SA), Italy;Department of Pharmacy, University of Salerno, Via Giovanni Paolo II 132, 84084 Fisciano (SA), Italy;Servicio de Microbiología, Hospital Universitario Son Espases, Instituto de Investigación Sanitaria de Palma (IdISPa), Ctra. Valldemossa 79, 07010 Palma de Mallorca, Spain;
关键词: azo-compound;    Gram-positive antibacterial;    listeria monocytogenes;    synthesis;   
DOI  :  10.3390/molecules22081372
来源: DOAJ
【 摘 要 】

Some novel (phenyl-diazenyl)phenols (4a–m) were designed and synthesized to be evaluated for their antibacterial activity. Starting from an active previously-synthesized azobenzene chosen as lead compound, we introduced some modifications and optimization of the structure, in order to improve solubility and drug conveyance. Structures of all newly-synthesized compounds were confirmed by 1H nuclear magnetic resonance (NMR), mass spectrometry, and UV-Vis spectroscopy. Antibacterial activity of the new compounds was tested with the dilution method against the bacteria strains Listeria monocytogenes, Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa PAO1. All the compounds were selectively active against Gram-positive bacteria. In particular, compounds 4d, 4h, and 4i showed the highest activity against S. aureus and Listeria monocytogenes, reaching remarkable MIC100 values of 4 μg/mL and 8 μg/mL. The relationship between antimicrobial activity and compound structure has suggested that the presence of hydroxyl groups seems to be essential for antimicrobial activity of phenolic compounds.

【 授权许可】

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