The emerging role of ferroptosis in inflammation

Biomedicine & Pharmacotherapy

Jiaheng Fang¹  Xin Chen¹  Bingtao Zhai¹  Yu Xiang²  Yufei Gao²  Peng Chen²  Guoxiong Li²  Mingming Zhang³  Xinbing Sui³  Sinan Xu³  Yitian Sun⁴ 

[1] Engineering Laboratory of Development and Application of Traditional Chinese Medicine from Zhejiang Province, Hangzhou 310018, Zhejiang, China;Key Laboratory of Elemene Class Anti-cancer Chinese Medicine of Zhejiang Province and Engineering Laboratory of Development and Application of Traditional Chinese Medicine from Zhejiang Province, Hangzhou Normal University, Hangzhou 310018, Zhejiang, China;Holistic Integrative Pharmacy Institutes and Department of Medical Oncology, the Affiliated Hospital of Hangzhou Normal University, College of Medicine, Hangzhou Normal University, Hangzhou 311121, Zhejiang, China;The Affiliated Hospital of Hangzhou Normal University, Hangzhou Normal University, Hangzhou 310015, Zhejiang, China;

关键词: Ferroptosis;    Inflammation;    Anti-inflammatory;   

DOI  :  

来源: DOAJ

【 摘 要 】

Ferroptosis is a newly discovered type of cell death triggered by intracellular phospholipid peroxidation that is morphologically, biologically and genetically distinct from other types of cell death. Ferroptosis is classified as regulated necrosis and is more immunogenic than apoptosis. To date, compelling evidence indicates that ferroptosis plays an important role in inflammation, and several antioxidants functioning as ferroptosis inhibitors have been shown to exert anti-inflammatory effects in experimental models of certain diseases. Our review provides an overview of the link between ferroptosis and inflammation; a better understanding of the mechanisms underlying ferroptosis and inflammation may hasten the development of promising therapeutic strategies involving ferroptosis inhibitors to address inflammation.

【 授权许可】

Unknown