Airway Epithelial Dynamics in Allergy and Related Chronic Inflammatory Airway Diseases

Frontiers in Cell and Developmental Biology

Robert Kern¹  Annika Luukkainen³  Anu Laulajainen-Hongisto⁴  Sanna Katriina Toppila-Salmi⁵ 

[1] Department of Otolaryngology, Northwestern University Feinberg School of Medicine, Chicago, IL, United States;Department of Otorhinolaryngology, Helsinki University Hospital, University of Helsinki, Helsinki, Finland;Haartman Institute, Medicum, University of Helsinki, Helsinki, Finland;Laboratory of Cellular and Molecular Immunology, Institute of Microbiology of the Czech Academy of Sciences, Prague, Czechia;Skin and Allergy Hospital, Helsinki University Hospital and University of Helsinki, Helsinki, Finland;

关键词: asthma;    chronic rhinosinusitis;    epithelium;    allergic rhinitis (AR);    inflammation;   

DOI  :  10.3389/fcell.2020.00204

来源: DOAJ

【 摘 要 】

Allergic rhinitis, chronic rhinosinusitis, and asthma are highly prevalent, multifactorial chronic airway diseases. Several environmental and genetic factors affect airway epithelial dynamics leading to activation of inflammatory mechanisms in the airways. This review links environmental factors to host epithelial immunity in airway diseases. Understanding altered homeostasis of the airway epithelium might provide important targets for diagnostics and therapy of chronic airway diseases.

【 授权许可】

Unknown