A retrospective, cross‐sectional study reveals that women with CRSwNP have more severe disease than men

Immunity, Inflammation and Disease

Whitney W. Stevens¹  Anju T. Peters¹  Lydia Suh¹  James E. Norton¹  Robert C. Kern²  David B. Conley²  Rakesh K. Chandra²  Bruce K. Tan²  Leslie C. Grammer III¹  Kathleen E. Harris¹  Roderick G. Carter¹  Atsushi Kato¹  Margrit Urbanek³  Robert P. Schleimer¹ 

[1] Division of Allergy-Immunology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA;Department of Otolaryngology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA;Division of Endocrinology, Metabolism and Molecular Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA

关键词: AERD;    asthma;    chronic inflammation;    chronic rhinosinusitis;    oral steroids;   

DOI  :  10.1002/iid3.46

来源: Wiley

【 摘 要 】

Abstract

Up to 50% of patients with chronic rhinosinusitis (CRS) have comorbid asthma, and we have reported that a subset of CRS patients who have nasal polyps (CRSwNP) have elevated autoantigen-specific antibodies within their nasal polyps (NP). While increases in the prevalence and/or severity of both asthma and autoimmunity in women are well characterized, it is not known whether CRSwNP is more severe or frequent in women than men. We sought to determine whether CRSwNP demonstrated sex-specific differences in frequency and/or severity. Using a retrospectively collected database of tertiary care patients (n = 1393), we evaluated the distribution of sex in patients with CRSwNP with or without comorbid asthma or aspirin hypersensitivity. We further compared the severity of sinus disease between men and women with CRSwNP. Although women comprised 55% of CRS patients without NP (CRSsNP), a significantly smaller proportion of CRSwNP patients were female (38%, P < 0.001). Interestingly, women with CRSwNP were significantly more likely than men to have comorbid asthma (P < 0.001), and 61% of patients with the most severe form of disease (aspirin-exacerbated respiratory disease (CRSwNP plus asthma plus aspirin sensitivity)) were women (P < 0.05). Women with CRSwNP were significantly more likely to have taken oral steroids, and were more likely to have a history of revision surgeries (P < 0.05) compared to men. These data suggest that women with CRSwNP have more severe disease than men in a tertiary care setting. Future studies are needed to elucidate the mechanisms that drive disease severity in men and women, paving the way for the development of personalized treatment strategies for CRSwNP based on sex.

【 授权许可】

CC BY-NC   
© 2015 The Authors. Immunity, Inflammation and DiseasePublished by John Wiley & Sons Ltd.

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