The FGF-21 genetic variants rs838133 and rs838145 are associated with high salt intake in the Emirati population

Journal of Advanced Research

Peter Habib¹  Hadia Radwan²  Shaista Manzoor³  Rahaf Wardeh⁴  Sarah Hammoudeh⁴  Rifat Hamoudi⁴  Hussein Jabbar⁵  Alsamman M. Alsamman⁵  Maha Saber-Ayad⁵  Ahmed Ashraf⁶ 

[1] Clinical Nutrition and Dietetics Department, College of Health Sciences, University of Sharjah, Sharjah, United Arab Emirates;College of Medicine, Cairo University, Cairo, Egypt;Corresponding author at: M27-191 College of Medicine, University of Sharjah, 27272 Sharjah, UAE.;Research Institute for Medical and Health Sciences, University of Sharjah, Sharjah, United Arab Emirates;College of Medicine, University of Sharjah, Sharjah, United Arab Emirates;Research Institute for Medical and Health Sciences, University of Sharjah, Sharjah, United Arab Emirates;

关键词: Salt intake;    Food intake;    FGF21;    United Arab Emirates;    Food Frequency Questionnaire (FFQ);    Multiple correspondence analysis;   

DOI  :  

来源: DOAJ

【 摘 要 】

Food predilection is linked to variants in the hepatokine “Fibroblast Growth Factor-21” gene (FGF21); with rs838133 linked to the sweet tooth in Caucasians. The effect of FGF21 variants on food intake is still unclear in other populations. A cohort of 196 healthy Emirati subjects was investigated [age: 30.34 ± 9.75yrs (44.4% males)]. The FGF21 rs838133 and rs838145 were genotyped. The daily intake was calculated based on a 61-item food frequency questionnaire. Multivariate analysis was performed using in house R script that implements two-way unsupervised hierarchical clustering to detect the association of the studied single-nucleotide polymorphisms (SNPs) and related SNPs in linkage disequilibrium, using data from the 1000 genome project. Both SNPs were in Hardy-Weinberg Equilaribium (HWE). BMI positively correlated with age (p = 0.002), but not with caloric intake. Salt intake was significantly higher in subjects homozygous (A: rs838133) and (G:rs838145),(p = 0.03 and 0.01, respectively). An interaction was observed between both SNPs; significantly associated with high salt intake. Using publicly available data, both SNPs fall within a region transmitted in Iberians which has a profile closely similar to Caucasians, but far from Chinese population. In conclusion, the minor alleles of FGF21 rs838145 and rs838133 are associated with high salt intake in Emiratis and may suggest neuro-metabolic link to dietary preference across different populations.

【 授权许可】

Unknown