Clinical Application of Silver Nanoparticles Coated by Benzalkonium Chloride

Coatings

Shakeel Ahmed Ansari¹  Asim Muhammed Alshanberi² 

[1] Department of Biochemistry, School of Medicine, Batterjee Medical College for Sciences and Technology, Jeddah 21442, Saudi Arabia;Department of Community Medicine and Pilgrims Health Care, Umm Alqura University, Makkah 24382, Saudi Arabia;

关键词: antimicrobial;    green nanotechnology;    silver nanoparticles;    quaternary ammonium salts;   

DOI  :  10.3390/coatings11111382

来源: DOAJ

【 摘 要 】

The present study investigates the surface modification of AgNPs (synthesized by neem leaves) by benzalkonium chloride (BAC). It was observed that 22 × 10⁹ CFU were formed at 0.25 mM AgNPs concentration. However, it was reduced to 14 × 10⁹ CFU for BAC-coated AgNPs at similar experimental conditions. The enzymatic activity of β-glucosidase was significantly enhanced from 0.0625 mM to 0.5 mM concentration of AgNPs, as well as BAC–AgNPs. However, there was no further change of activity beyond this concentration. ZOI of AgNPs and BAC–AgNPs was measured against E. coli, B. subtilis, P. aeruginosa, and S pneumoniae at 0.25 mM and 0.50 mM concentrations of these bioactive agents. ZOI was 3.45 cm and 3.56 cm for AgNPs and BAC–AgNPs at 0.25 mM of these bioactive agents, respectively, against E. coli. However, these values were 4.28 cm and 4.40 cm, respectively, against B. subtilis. ZOI was obtained at 3.36 cm and 3.47 cm, respectively, against P. aeruginosa under similar experimental concentrations. However, ZOI was achieved at 3.44 cm and 3.62 cm, respectively, against S. pneumonia, under similar experimental conditions. Hence, such research findings can be exploited for potential applications in numerous environmental and biomedical fields.

【 授权许可】

Unknown