Vaccination against Paediatric Respiratory Pathogens

Vaccines

Anna Alunno¹  Barbara Camilloni¹  Ettore Silvestri²  Sonia Bianchini²  Alberto Argentiero²  Susanna Esposito³ 

[1] Microbiology Unit, Department of Medicine, Università degli Studi di Perugia, 06123 Perugia, Italy;Pediatric Clinic, Department of Surgical and Biomedical Sciences, Università degli Studi di Perugia, 06123 Perugia, Italy;Pietro Barilla Children’s Hospital, Department of Medicine and Surgery, University of Parma, 43126 Parma, Italy;

关键词: respiratory pathogen;    vaccine;    children;    complication;    outbreak;    infection;   

DOI  :  10.3390/vaccines7040168

来源: DOAJ

【 摘 要 】

Acute respiratory infections (ARIs) are extremely common in children, especially those under 5 years old. They can lead to complications, super-infection, respiratory failure, and even compromised respiratory function in adulthood. For some of the responsible pathogens, vaccines are available. This review reports current issues about vaccines against the main respiratory pathogens to highlight the available strategies to reduce the burden of paediatric respiratory disease. The optimal use of influenza, pneumococcal, pertussis and measles vaccines is required in order to reduce ARI burden. Vaccination coverage rates must be improved to achieve the full benefits of these vaccines. Recently, advances in the knowledge of respiratory syncytial virus structural biology and immunology as well as the development of new techniques to generate vaccine candidates have increased the number of promising vaccines even against this harmful pathogen.

【 授权许可】

Unknown