Connections for Matters of the Heart: Network Medicine in Cardiovascular Diseases

Frontiers in Cardiovascular Medicine

Elena Aikawa¹  Masanori Aikawa¹  Abhijeet Rajendra Sonawane¹ 

[1] Center for Excellence in Vascular Biology, Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, United States;Center for Interdisciplinary Cardiovascular Sciences, Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, United States;

关键词: network medicine;    cardiovascular disease;    systems biology;    protein–protein interaction (PPI);    gene regulatory network (GRN);    coexpression network;   

DOI  :  10.3389/fcvm.2022.873582

来源: DOAJ

【 摘 要 】

Cardiovascular diseases (CVD) are diverse disorders affecting the heart and vasculature in millions of people worldwide. Like other fields, CVD research has benefitted from the deluge of multiomics biomedical data. Current CVD research focuses on disease etiologies and mechanisms, identifying disease biomarkers, developing appropriate therapies and drugs, and stratifying patients into correct disease endotypes. Systems biology offers an alternative to traditional reductionist approaches and provides impetus for a comprehensive outlook toward diseases. As a focus area, network medicine specifically aids the translational aspect of in silico research. This review discusses the approach of network medicine and its application to CVD research.

【 授权许可】

Unknown