Dyslipidemia and non-small cell lung cancer risk in Chinese population: a case-control study

Lipids in Health and Disease

Miaomei Yu¹  Bo Hao²  Jiajun Chen²  Baochen Bi³  Chen Sang³ 

[1] Comprehensive Laboratory, the Third Affiliated Hospital of Soochow University;Department of Cardiothoracic Surgery, Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science;Department of Cardiothoracic Surgery, the Third Affiliated Hospital of Soochow University;

关键词: Dyslipidemia;    Risk;    Non-small cell lung cancer;    Triglyceride;    High-density lipoprotein cholesterol;   

DOI  :  10.1186/s12944-018-0925-z

来源: DOAJ

【 摘 要 】

Abstract Background Numerous studies reported that dyslipidemia was associated with cancer risk. However, few studies investigated the associations between dyslipidemia and non-small cell lung cancer (NSCLC). Methods Four hundred twenty-four histologically confirmed NSCLC cases and 414 controls, matched for age and sex, were enrolled to examine the relationship between dyslipidemia and NSCLC. Demographic and clinical data were obtained from patients’ medical records and telephone interviews. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using unconditional logistic regression. Results Abnormal triglyceride (TG) and high-density lipoprotein cholesterol (HDL-C) levels showed statistically significant coexistence with NSCLC compared with controls. Higher levels of TG were associated with a higher risk of NSCLC (OR = 1.541, 95% CI, (1.072–2.215)). The odds ratios (ORs) for NSCLC for normal and high levels of HDL-C versus those with a low level of HDL-C were 0.337(95% CI, (0.242–0.468)) and 0.288(95% CI, (0.185–0.448)), respectively. After adjustment for age, sex, smoking status, hypertension, body mass index, diabetes and lipid profiles, the adjusted OR for normal and high levels of HDL-C were 0.320(95% CI, (0.218–0.470)) and 0.233(95% CI, (0.134–0.407)), respectively. However, after adjustment, high levels of TG increased the risk of NSCLC but not significantly (OR = 1.052, 95% CI (0.671–1.649)). Conclusions This study provided evidence that dyslipidemia increased the risk of NSCLC in Chinese population.

【 授权许可】

Unknown