Adropin as A Fat-Burning Hormone with Multiple Functions—Review of a Decade of Research

Molecules

Marek Skrzypski¹  Mariami Jasaszwili¹  Maria Billert¹  KrzysztofW. Nowak¹  MathiasZ. Strowski² 

[1] Department of Animal Physiology and Biochemistry, Poznań University of Life Sciences, 60-637 Poznań, Poland;Department of Hepatology and Gastroenterology, Charité-University Medicine Berlin, D-13353 Berlin, Germany;

关键词: adropin;    enho;    adiposity;    metabolism;    type 2 diabetes;    liver;    cancer;    cardiovascular system;   

DOI  :  10.3390/molecules25030549

来源: DOAJ

【 摘 要 】

Adropin is a unique hormone encoded by the energy homeostasis-associated (Enho) gene. Adropin is produced in the liver and brain, and also in peripheral tissues such as in the heart and gastrointestinal tract. Furthermore, adropin is present in the circulatory system. A decade after its discovery, there is evidence that adropin may contribute to body weight regulation, glucose and lipid homeostasis, and cardiovascular system functions. In this review, we summarize and discuss the physiological, metabolic, and pathophysiological factors regulating Enho as well as adropin. Furthermore, we review the literature addressing the role of adropin in adiposity and type 2 diabetes. Finally, we elaborate on the role of adropin in the context of the cardiovascular system, liver diseases, and cancer.

【 授权许可】

Unknown