Oxysterols from a Marine Sponge Inflatella sp. and Their Action in 6-Hydroxydopamine-Induced Cell Model of Parkinson’s Disease

Marine Drugs

SophiaA. Kolesnikova¹  EkaterinaA. Yurchenko¹  AnatolyI. Kalinovsky¹  EkaterinaG. Lyakhova¹  ValentinA. Stonik¹  RomanS. Popov¹ 

[1] G.B. Elyakov Pacific Institute of Bioorganic Chemistry (PIBOC), Prospect 100-let Vladivostoku 159, Vladivostok 690022, Russia;

关键词: secondary metabolites;    oxygenated steroids;    marine sponge;    Inflatella;    NMR;    ROS;    Parkinson’s disease;    structure-activity relationship;   

DOI  :  10.3390/md16110458

来源: DOAJ

【 摘 要 】

Four new oxysterols 1⁻4 along with previously known oxygenated sterols 5⁻14 were isolated from the sponge Inflatella sp., collected from the Sea of Okhotsk. Structures of 1⁻4 were elucidated by the detailed NMR spectroscopic and mass-spectrometric analyses as well as by comparison of the corresponding experimental data with those reported in literature. The influence of compounds 1⁻14 on the viability of neuronal Neuro2a cells treated by 6-hydroxydopamine and reactive oxygen species (ROS) formation in these cells was investigated.

【 授权许可】

Unknown