期刊论文详细信息
Marine Drugs | |
Oxysterols from a Marine Sponge Inflatella sp. and Their Action in 6-Hydroxydopamine-Induced Cell Model of Parkinson’s Disease | |
SophiaA. Kolesnikova1  EkaterinaA. Yurchenko1  AnatolyI. Kalinovsky1  EkaterinaG. Lyakhova1  ValentinA. Stonik1  RomanS. Popov1  | |
[1] G.B. Elyakov Pacific Institute of Bioorganic Chemistry (PIBOC), Prospect 100-let Vladivostoku 159, Vladivostok 690022, Russia; | |
关键词: secondary metabolites; oxygenated steroids; marine sponge; Inflatella; NMR; ROS; Parkinson’s disease; structure-activity relationship; | |
DOI : 10.3390/md16110458 | |
来源: DOAJ |
【 摘 要 】
Four new oxysterols 1⁻4 along with previously known oxygenated sterols 5⁻14 were isolated from the sponge Inflatella sp., collected from the Sea of Okhotsk. Structures of 1⁻4 were elucidated by the detailed NMR spectroscopic and mass-spectrometric analyses as well as by comparison of the corresponding experimental data with those reported in literature. The influence of compounds 1⁻14 on the viability of neuronal Neuro2a cells treated by 6-hydroxydopamine and reactive oxygen species (ROS) formation in these cells was investigated.
【 授权许可】
Unknown