Poly(α-hydroxy Acids)-Based Cell Microcarriers

Applied Sciences

Jose-Ramon Sarasua¹  Aitor Larrañaga² 

[1] POLYMAT, Faculty of Engineering, University of the Basque Country (UPV/EHU), Bilbao 480130, Spain;;Department of Mining-Metallurgy Engineering and Materials Science &

关键词: polylactide;    poly(α-hydroxyacids);    cell microcarriers;    microparticles;    tissue engineering;   

DOI  :  10.3390/app6120436

来源: DOAJ

【 摘 要 】

Biodegradable poly(α-hydroxyacids) have gained increasing interest in the biomedical field for their use as cell microcarriers thanks to their biodegradability, biocompatibility, tunable mechanical properties/degradation rates and processability. The synthesis of these poly(α-hydroxyacids) can be finely controlled to yield (co)polymers of desired mechanical properties and degradation rates. On the other hand, by simple emulsion-solvent evaporation techniques, microspheres of controlled size and size distribution can be fabricated. The resulting microspheres can be further surface-modified to enhance cell adhesion and proliferation. As a result of this process, biodegradable microcarriers with advanced functionalities and surface properties that can be directly employed as injectable cell microcarriers are obtained.

【 授权许可】

Unknown