Efficient Diethylzinc/Gallic Acid and Diethylzinc/Gallic Acid Ester Catalytic Systems for the Ring-Opening Polymerization of rac-Lactide

Molecules

Karolina Żółtowska¹  Urszula Piotrowska¹  Ewa Oledzka¹  Marcin Sobczak¹ 

[1] Department of Inorganic and Analytical Chemistry, Faculty of Pharmacy and Division of Laboratory Medicine, Medical University of Warsaw, 1 Banacha St., Warsaw 02-097, Poland;

关键词: biomedical polymers;    polylactide;    ring-opening polymerization;    zinc-based catalysts;    gallic acid;    propyl gallate;   

DOI  :  10.3390/molecules201219815

来源: mdpi

【 摘 要 】

Polylactide (PLA) represents one of the most promising biomedical polymers due to its biodegradability, bioresorbability and good biocompatibility. This work highlights the synthesis and characterization of PLAs using novel diethylzinc/gallic acid (ZnEt₂/GAc) and diethylzinc/propyl gallate (ZnEt₂/PGAc) catalytic systems that are safe for human body. The results of the ring-opening polymerization (ROP) of rac-lactide (rac-LA) in the presence of zinc-based catalytic systems have shown that, depending on the reaction conditions, “predominantly isotactic”, disyndiotactic or atactic PLA can be obtained. Therefore, the controlled and stereoselective ROP of rac-LA is discussed in detail in this paper.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.