Drosophila as a Model to Study the Mechanism of Nociception

Frontiers in Physiology

Botong Li¹  Shuzhen Han¹  Yuan Zhang¹  Kai Liu²  Minghui Xiu³  Jianzheng He⁴  Yongqi Liu⁴  Simeng Yi⁶ 

[1] College of Basic Medicine, Gansu University of Chinese Medicine, Lanzhou, China;College of Integrated Traditional Chinese and Western Medicine, Gansu University of Chinese Medicine, Lanzhou, China;College of Public Health, Gansu University of Chinese Medicine, Lanzhou, China;Key Laboratory for Transfer of Dunhuang Medicine at the Provincial and Ministerial Level, Gansu University of Chinese Medicine, Lanzhou, China;Provincial-Level Key Laboratory for Molecular Medicine of Major Diseases and the Prevention and Treatment with Traditional Chinese Medicine Research in Gansu Colleges and University, Gansu University of Chinese Medicine, Lanzhou, China;State Key Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, Beijing, China;

关键词: nociception;    conserved genetics;    nociceptive sensory neurons;    behavioral assay;    Drosophila melanogaster;   

DOI  :  10.3389/fphys.2022.854124

来源: DOAJ

【 摘 要 】

Nociception refers to the process of encoding and processing noxious stimuli, which allow animals to detect and avoid potentially harmful stimuli. Several types of stimuli can trigger nociceptive sensory transduction, including thermal, noxious chemicals, and harsh mechanical stimulation that depend on the corresponding nociceptors. In view of the high evolutionary conservation of the mechanisms that govern nociception from Drosophila melanogaster to mammals, investigation in the fruit fly Drosophila help us understand how the sensory nervous system works and what happen in nociception. Here, we present an overview of currently identified conserved genetics of nociception, the nociceptive sensory neurons responsible for detecting noxious stimuli, and various assays for evaluating different nociception. Finally, we cover development of anti-pain drug using fly model. These comparisons illustrate the value of using Drosophila as model for uncovering nociception mechanisms, which are essential for identifying new treatment goals and developing novel analgesics that are applicable to human health.

【 授权许可】

Unknown