Deciphering the Role of the Coagulation Cascade and Autophagy in Cancer-Related Thrombosis and Metastasis

Frontiers in Oncology

Begoña Torres²  Benjamin Solis²  Maria Paz Hernández-Cáceres²  Gareth I. Owen³  Charlotte Nicole Hill⁴  Catalina Asencio⁴ 

[1] Advanced Center for Chronic Diseases (ACCDiS), Santiago, Chile;Faculty of Biological Sciences, Pontificia Universidad Católica de Chile, Santiago, Chile;Faculty of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile;Millennium Institute on Immunology and Immunotherapy, Santiago, Chile;

关键词: cancer;    metastasis;    coagulation;    autophagy;    cancer-associated thrombosis;    megakaryopoeiesis and thrombopoiesis;   

DOI  :  10.3389/fonc.2020.605314

来源: DOAJ

【 摘 要 】

Thrombotic complications are the second leading cause of death among oncology patients worldwide. Enhanced thrombogenesis has multiple origins and may result from a deregulation of megakaryocyte platelet production in the bone marrow, the synthesis of coagulation factors in the liver, and coagulation factor signaling upon cancer and the tumor microenvironment (TME). While a hypercoagulable state has been attributed to factors such as thrombocytosis, enhanced platelet aggregation and Tissue Factor (TF) expression on cancer cells, further reports have suggested that coagulation factors can enhance metastasis through increased endothelial-cancer cell adhesion and enhanced endothelial cell activation. Autophagy is highly associated with cancer survival as a double-edged sword, as can both inhibit and promote cancer progression. In this review, we shall dissect the crosstalk between the coagulation cascade and autophagic pathway and its possible role in metastasis and cancer-associated thrombosis formation. The signaling of the coagulation cascade through the autophagic pathway within the hematopoietic stem cells, the endothelial cell and the cancer cell are discussed. Relevant to the coagulation cascade, we also examine the role of autophagy-related pathways in cancer treatment. In this review, we aim to bring to light possible new areas of cancer investigation and elucidate strategies for future therapeutic intervention.

【 授权许可】

Unknown