Nosocomial Candida Infections: Microbiological and Clinical Features

Flora Infeksiyon Hastalıkları ve Klinik Mikrobiyoloji Dergisi

Filiz KİBAR¹  Gülşah SEYDAOĞLU²  Hasan Salih Zeki AKSU³  Yeşim TAŞOVA³  Behice KURTARAN³  Ayşe Seza İNAL³  Neşe SALTOĞLU³  Aslıhan CANDEVİR³ 

[1] Central Laboratory, Faculty of Medicine, University of Cukurova, Adana, Turkey;Department of Biostatistical, Faculty of Medicine, University of Cukurova, Adana, Turkey;Department of Clinical Bacteriology and Infectious Diseases, Faculty of Medicine, University of Cukurova, Adana, Turkey;

关键词: Candida;    Infection;    Antifungal;    Susceptibility;   

DOI  :  

来源: DOAJ

【 摘 要 】

Introduction: Nosocomial infections due to Candida show significant mortality and morbidity in recent years. Since the diagnosis and treatment of fungal infections are difficult, they also add economical load to the healthcare. This study was designed to determine the epidemiology and anti-fungal sensitivity patterns of nosocomial Candida infections in our hospital. Patients and Methods: The patients hospitalized in the Cukurova University, Medical Faculty Hospital between 1 January 2004 and 30 July 2004 with nosocomial Candida infection were included in the study. CDC criteria were used for diagnosis of nosocomial infections. Candida spp. isolated as responsible from the nosocomial infection were investigated with ID32C (Biomerieux, France) for species identification. ATB Fungus 2 (Biomerieux, France) was used for antifungal susceptibility. SPSS 12.0 was used for data analysis. Student’s t-test and chi-square tests were used for statistical analysis. Results: A total of 160 patients were involved. In patients with candidiasis, the site of infection and their frequency were determined as bloodstream, urinary tract and other sites, being 42 (26.3%), 104 (65.0%) and 14 (8.7%) respectively. C. albicans (50.6%) that was the most prominent Candida species was followed by C. glabrata (16.3%), C. tropicalis (16.3%), C. parapsilosis (10.0%), C. krusei (3.1%), C. lusitaniae (1.2%) and one isolate each of C. kefyr, C. sake and C. pulcherrima. All isolates were sensitive to amphotericin B (MIC ≤ 1 µg/mL). Fluconazole resistance was 4.3% and 15.6% for C. albicans and for species other than C. albicans respectively. Resistance to itraconazole was found to be higher, which was 11.4% for C. albicans and 26.5% for other species. Cross resistance to itraconazole was determined in 12 of 13 (92.3%) isolates which were resistant to fluconazole. Conclusion: The high resistance to azoles which can be considered as an indicator of inappropriate antifungal therapy should be taken into consideration.

【 授权许可】

Unknown