Complement system and age-related macular degeneration: drugs and challenges

Drug Design, Development and Therapy

关键词: age-related macular degeneration;    inflammation;    complement system;    immunotherapy;   

DOI  :  

来源: DOAJ

【 摘 要 】

Jiali Wu,1 Xiaodong Sun1–31Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China; 2Shanghai Key Laboratory of Fundus Disease, Shanghai, People’s Republic of China; 3Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai, People’s Republic of ChinaAbstract: Age-related macular degeneration (AMD) is directly attributable to vision loss, posing significant pressure on public health. AMD is recognized to be a multi-factorial disease and among them, complement system is under heated discussion in recent years. In this review, we start with an overview of complement pathways involved in AMD and their therapies correspondingly. Finally, we discuss the development of the therapeutics existed now. Also, we enclose a list of drugs undergoing clinical trials.Keywords: age-related macular degeneration, inflammation, complement system, immunotherapy

【 授权许可】

Unknown