Complement System: An Immunotherapy Target in Colorectal Cancer

Frontiers in Immunology

Immunology

Noha Mousaad Elemam¹  Iman M. Talaat²  Maha Saber-Ayad³ 

[1] College of Medicine, University of Sharjah, Sharjah, United Arab Emirates;Sharjah Institute for Medical Research, University of Sharjah, Sharjah, United Arab Emirates;College of Medicine, University of Sharjah, Sharjah, United Arab Emirates;Sharjah Institute for Medical Research, University of Sharjah, Sharjah, United Arab Emirates;Faculty of Medicine, Alexandria University, Alexandria, Egypt;College of Medicine, University of Sharjah, Sharjah, United Arab Emirates;Sharjah Institute for Medical Research, University of Sharjah, Sharjah, United Arab Emirates;Faculty of Medicine, Cairo University, Cairo, Egypt;

关键词: complement system;    colorectal cancer;    immunotherapy;    tumor microenvironment;    tumor immunity;   

DOI  :  10.3389/fimmu.2022.810993

 received in 2021-11-08, accepted in 2022-01-14,  发布年份 2022

来源: Frontiers

【 摘 要 】

Colorectal cancer (CRC) is the third most common malignant tumor and the second most fatal cancer worldwide. Several parts of the immune system contribute to fighting cancer including the innate complement system. The complement system is composed of several players, namely component molecules, regulators and receptors. In this review, we discuss the complement system activation in cancer specifically CRC and highlight the possible interactions between the complement system and the various TME components. Additionally, the role of the complement system in tumor immunity of CRC is reviewed. Hence, such work could provide a framework for researchers to further understand the role of the complement system in CRC and explore the potential therapies targeting complement activation in solid tumors such as CRC.

【 授权许可】

Unknown   
Copyright © 2022 Talaat, Elemam and Saber-Ayad