Real-Time Dual-Wavelength Time-Resolved Diffuse Optical Tomography System for Functional Brain Imaging Based on Probe-Hosted Silicon Photomultipliers

Sensors

David Orive-Miguel¹  Lionel Hervé¹  Laura Di Sieno²  Antonio Pifferi²  Davide Contini²  Alberto Dalla Mora²  Anurag Behera²  Alessandro Torricelli²  Edoardo Ferocino²  Jérôme Mars³  Laurent Condat⁴ 

[1] CEA, LETI, MINATEC Campus, F-38054 Grenoble, France;Politecnico di Milano, Dipartimento di Fisica, 20133 Milano, Italy;University Grenoble Alpes, CNRS, Grenoble INP, GIPSA-Lab, 38000 Grenoble, France;Visual Computing Center, King Abdullah University of Science and Technology (KAUST), Thuwal 23955-6900, Saudi Arabia;

关键词: diffuse optical tomography;    time-correlated single-photon counting;    silicon photomultipliers;    functional imaging;   

DOI  :  10.3390/s20102815

来源: DOAJ

【 摘 要 】

Near-infrared diffuse optical tomography is a non-invasive photonics-based imaging technology suited to functional brain imaging applications. Recent developments have proved that it is possible to build a compact time-domain diffuse optical tomography system based on silicon photomultipliers (SiPM) detectors. The system presented in this paper was equipped with the same eight SiPM probe-hosted detectors, but was upgraded with six injection fibers to shine the sample at several points. Moreover, an automatic switch was included enabling a complete measurement to be performed in less than one second. Further, the system was provided with a dual-wavelength ( 670 $\mathrm{n}$ $\mathrm{m}$ and 820 $\mathrm{n}$ $\mathrm{m}$ ) light source to quantify the oxy- and deoxy-hemoglobin concentration evolution in the tissue. This novel system was challenged against a solid phantom experiment, and two in-vivo tests, namely arm occlusion and motor cortex brain activation. The results show that the tomographic system makes it possible to follow the evolution of brain activation over time with a 1 $\mathrm{s}$ -resolution.

【 授权许可】

Unknown