Time-Domain Functional Diffuse Optical Tomography System Based on Fiber-Free Silicon Photomultipliers

Applied Sciences

Andrea Farina¹  Antonio Pifferi¹  Alessandro Torricelli¹  Simon Arridge²  Fabrizio Martelli³  Susanna Tagliabue⁴  Turgut Durduran⁴  Alberto Dalla Mora⁵  Laura Di Sieno⁵  Edoardo Martinenghi⁵ 

[1] Consiglio Nazionale delle Ricerche, Istituto di Fotonica e Nanotecnologie, Piazza Leonardo da Vinci 32, 20133 Milano, Italy;Department of Computer Science, University College London, Gower Street, London WC1E 6BT, UK;Dipartimento di Fisica e Astronomia dell’Università degli Studi di Firenze, Via G. Sansone 1, Sesto Fiorentino, 50019 Firenze, Italy;ICFO-Institut de Ciències Fotòniques, The Barcelona Institute of Science and Technology, Av. Carl Friedrich Gauss, 3, 08860 Barcelona, Spain;Politecnico di Milano, Dipartimento di Fisica, Piazza Leonardo da Vinci 32, 20133 Milano, Italy;

关键词: functional imaging;    diffuse optical tomography;    time-correlated single-photon counting;    silicon photomultipliers;   

DOI  :  10.3390/app7121235

来源: DOAJ

【 摘 要 】

Based on recent developments in both single-photon detectors and timing electronic circuits, we designed a compact and cost effective time-domain diffuse optical tomography system operated at 1 Hz acquisition rate, based on eight silicon photomultipliers and an 8-channel time-to-digital converter. The compact detectors are directly hosted on the probe in a circular arrangement around a single light injection fiber, so to maximize light harvesting. Tomography is achieved exploiting the depth sensitivity that is encoded in the arrival time of detected photons. The system performances were evaluated on simulations to assess possible the limitations arising from the use of a single injection point, and then on phantoms and in vivo to prove the eligibility of these technologies for diffuse optical tomography.

【 授权许可】

Unknown