Vesicular Stomatitis Virus: From Agricultural Pathogen to Vaccine Vector

Pathogens

Wenjun Zhu¹  Abdjeleel Salawudeen²  Karla Emeterio³  Logan Banadyga³  David Safronetz³  Wenguang Cao³  Guodong Liu³ 

[1] Canadian Food Inspection Agency, National Centre for Foreign Animal Disease, Winnipeg, MB R3E 3M4, Canada;Department of Medical Microbiology and Infectious Diseases, University of Manitoba, Winnipeg, MB R3E 0J9, Canada;Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, MB R3E 3R2, Canada;

关键词: vesicular stomatitis virus;    VSV;    vaccine;    countermeasure;    Ebola virus;    VSV-EBOV;   

DOI  :  10.3390/pathogens10091092

来源: DOAJ

【 摘 要 】

Vesicular stomatitis virus (VSV), which belongs to the Vesiculovirus genus of the family Rhabdoviridae, is a well studied livestock pathogen and prototypic non-segmented, negative-sense RNA virus. Although VSV is responsible for causing economically significant outbreaks of vesicular stomatitis in cattle, horses, and swine, the virus also represents a valuable research tool for molecular biologists and virologists. Indeed, the establishment of a reverse genetics system for the recovery of infectious VSV from cDNA transformed the utility of this virus and paved the way for its use as a vaccine vector. A highly effective VSV-based vaccine against Ebola virus recently received clinical approval, and many other VSV-based vaccines have been developed, particularly for high-consequence viruses. This review seeks to provide a holistic but concise overview of VSV, covering the virus’s ascension from perennial agricultural scourge to promising medical countermeasure, with a particular focus on vaccines.

【 授权许可】

Unknown