Nuclear Imprisonment: Viral Strategies to Arrest Host mRNA Nuclear Export

Viruses

Sharon K. Kuss¹  Miguel A. Mata²  Liang Zhang² 

[1] Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA;

关键词: virus;    influenza virus;    vesicular stomatitis virus;    VSV;    NS1;    matrix protein;    nuclear export;    nucleo-cytoplasmic trafficking;    mRNA export;    NXF1;    TAP;    CRM1;    Rae1;   

DOI  :  10.3390/v5071824

来源: mdpi

【 摘 要 】

Viruses possess many strategies to impair host cellular responses to infection. Nuclear export of host messenger RNAs (mRNA) that encode antiviral factors is critical for antiviral protein production and control of viral infections. Several viruses have evolved sophisticated strategies to inhibit nuclear export of host mRNAs, including targeting mRNA export factors and nucleoporins to compromise their roles in nucleo-cytoplasmic trafficking of cellular mRNA. Here, we present a review of research focused on suppression of host mRNA nuclear export by viruses, including influenza A virus and vesicular stomatitis virus, and the impact of this viral suppression on host antiviral responses.

【 授权许可】

CC BY   
© 2013 by the authors; licensee MDPI, Basel, Switzerland.