Epidemiology and Pattern of Resistance of Gram-Negative Bacteria Isolated from Blood Samples in Hospitalized Patients: A Single Center Retrospective Analysis from Southern Italy

Antibiotics

Consolato Maria Sergi¹  Paola Di Carlo²  Maria Santa Napolitano²  Antonio Cascio²  Anna Giammanco²  Teresa Fasciana²  Teresa Rea³  Nicola Serra³  Sofia Lo Sauro⁴  Alessandro Lucchesi⁵  Juan Camilo Signorello⁶  Giuseppe Manta⁷  Vincenza Maria Carelli⁸  Maurizio Giarratana⁸ 

[1] Children’s Hospital of Eastern Ontario, University of Ottawa, Ottawa, ON K1H 8L1, Canada;Department of Health Promotion, Maternal-Childhood, Internal Medicine of Excellence G. D’Alessandro, University of Palermo, 90127 Palermo, Italy;Department of Public Health, University Federico II of Naples, 80131 Napoli, Italy;Emergency Unit, Umberto I Hospital, 94100 Enna, Italy;Hematology Unit, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS, 47014 Meldola, Italy;Hypatia School of Medicine (UNIPA-Caltanissetta), University of Palermo, 90127 Palermo, Italy;Intensive Cure Unit (ICU), Sant’Elia Hospital, 93100 Caltanissetta, Italy;Microbiology Unit, Sant’Elia Hospital, 93100 Caltanissetta, Italy;

关键词: bacteria;    survival time;    MDR;    infection;   

DOI  :  10.3390/antibiotics10111402

来源: DOAJ

【 摘 要 】

Background: Blood culturing remains the mainstream tool to inform an appropriate treatment in hospital-acquired bloodstream infections and to diagnose any bacteremia. Methods: A retrospective investigation on the prevalence of Gram-negative bacteria (GNB) and their resistance in hospitalized patients by age, sex, and units from blood cultures (BCs) was conducted from January 2018 to April 2020 at Sant’Elia hospital, Caltanissetta, southern Italy. We divided the patient age range into four equal intervals. Results: Multivariate demographic and microbiological variables did not show an association between bacteria distributions and gender and age. The distribution by units showed a higher prevalence of Klebsiella pneumoniae and Acinetobacter baumannii in the intensive care unit (ICU) and Escherichia coli in the non-intensive care units (non-ICUs). The analysis of antibiotic resistance showed that E. coli was susceptible to a large class of antibiotics such as carbapenem and trimethoprim-sulfamethoxazole. K. pneumoniae showed a significant susceptibility to colistin, tigecycline, and trimethoprim-sulfamethoxazole. From the survival analysis, patients with E. coli had a higher survival rate. Conclusions: The authors stress the importance of the implementation of large community-level programs to prevent E. coli bacteremia. K. pneumoniae and E. coli susceptibility patterns to antibiotics, including in the prescription patterns of general practitioners, suggest that the local surveillance and implementation of educational programs remain essential measures to slow down the spread of resistance and, consequently, increase the antibiotic lifespan.

【 授权许可】

Unknown