The Role of Nrf2 in the Antioxidant Cellular Response to Medical Ozone Exposure

International Journal of Molecular Sciences

Mirco Galiè¹  Manuela Malatesta¹  Gabriele Tabaracci²  Viviana Covi² 

[1] Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Strada Le Grazie 8, I-37134 Verona, Italy;San Rocco Clinic, Via Monsignor G. V. Moreni 95, I-25018 Montichiari (BS), Italy;

关键词: ozone therapy;    oxidative stress;    proteostasis;    mitochondria;    inflammation;    adipose biology;    cancer;   

DOI  :  10.3390/ijms20164009

来源: DOAJ

【 摘 要 】

Ozone (O₃) is a natural, highly unstable atmospheric gas that rapidly decomposes to oxygen. Although not being a radical molecule, O₃ is a very strong oxidant and therefore it is potentially toxic for living organisms. However, scientific evidence proved that the effects of O₃ exposure are dose-dependent: high dosages stimulate severe oxidative stress resulting in inflammatory response and tissue injury, whereas low O₃ concentrations induce a moderate oxidative eustress activating antioxidant pathways. These properties make O₃ a powerful medical tool, which can be used as either a disinfectant or an adjuvant agent in the therapy of numerous diseases. In this paper, the cellular mechanisms involved in the antioxidant response to O₃ exposure will be reviewed with special reference to the activation of nuclear factor erythroid 2-related factor 2 (Nrf2) and its role in the efficacy of ozone therapy.

【 授权许可】

Unknown