Gnawing Between Cells and Cells in the Immune System: Friend or Foe? A Review of Trogocytosis

Frontiers in Immunology

Siyu Zhao³  Yunyi Hu³  Jia Shen³  Lichao Zhang³  Suoyu Xiang³  Zhongdao Wu³ 

[1] Department of Parasitology of Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China;Key Laboratory of Tropical Disease Control (SYSU), Ministry of Education, Guangzhou, China;Provincial Engineering Technology Research Center for Biological Vector Control, Guangzhou, China;

关键词: trogocytosis;    information transmission;    immune defense;    immune escape;    immune regulation;   

DOI  :  10.3389/fimmu.2022.791006

来源: DOAJ

【 摘 要 】

Trogocytosis occurs when one cell contacts and quickly nibbles another cell and is characterized by contact between living cells and rapid transfer of membrane fragments with functional integrity. Many immune cells are involved in this process, such as T cells, B cells, NK cells, APCs. The transferred membrane molecules including MHC molecules, costimulatory molecules, receptors, antigens, etc. An increasing number of studies have shown that trogocytosis plays an important role in the immune system and the occurrence of relevant diseases. Thus, whether trogocytosis is a friend or foe of the immune system is puzzling, and the precise mechanism underlying it has not yet been fully elucidated. Here, we provide an integrated view of the acquired findings on the connections between trogocytosis and the immune system.

【 授权许可】

Unknown