Kynurenic Acid and Its Analogs Are Beneficial Physiologic Attenuators in Bdelloid Rotifers

Molecules

Bence Galik¹  Denes Zadori²  Janos Kalman³  Zsolt Datki³  Zita Galik-Olah³  Istvan Szatmari⁴  Ferenc Fulop⁴  Zsuzsanna Bohar⁵  Laszlo Vecsei⁵ 

[1] Department of Clinical Molecular Biology, Medical University of Bialystok, ul.Jana Kilinskiego 1, 15-089 Bialystok, Poland;Department of Neurology, Interdisciplinary Excellence Centre, Faculty of Medicine, University of Szeged, Semmelweis u. 6, H-6725 Szeged, Hungary;Department of Psychiatry, Faculty of Medicine, University of Szeged, Kalvaria sgt. 57, H-6725 Szeged, Hungary;Institute of Pharmaceutical Chemistry, Interdisciplinary Excellence Centre, Faculty of Pharmacy, University of Szeged, Eötvös u. 6, H-6720 Szeged, Hungary;MTA-SZTE Neuroscience Research Group, Semmelweis u. 6, H-6725 Szeged, Hungary;

关键词: kynurenic acid;    metabolism;    physiology;    bdelloid rotifer;    survival;    mastax;   

DOI  :  10.3390/molecules24112171

来源: DOAJ

【 摘 要 】

The in vivo investigation of kynurenic acid (KYNA) and its analogs is one of the recent exciting topics in pharmacology. In the current study we assessed the biological effects of these molecules on bdelloid rotifers (Philodina acuticornis and Adineta vaga) by monitoring changes in their survival and phenotypical characteristics. In addition to longitudinal (slowly changing) markers (survival, number of rotifers alive and body size index), some dynamic (quickly responding) ones (cellular reduction capacity and mastax contraction frequency) were measured as well. KYNA and its analogs increased longevity, reproduction and growth, whereas reduction capacity and energy-dependent muscular activity decreased conversely. We found that spermidine, a calorie restriction mimetic, exerted similar changes in the applied micro-invertebrates. This characterized systemic profile evoked by the above-mentioned compounds was named beneficial physiologic attenuation. In reference experiments, using a stimulator (cyclic adenosine monophosphate) and a toxin (sodium azide), all parameters changed in the same direction (positively or negatively, respectively), as expected. The currently described adaptive phenomenon in bdelloid rotifers may provide holistic perspectives in translational research.

【 授权许可】

Unknown