Moderate Physical Activity as a Prevention Method for Knee Osteoarthritis and the Role of Synoviocytes as Biological Key

International Journal of Molecular Sciences

Silvia Ravalli¹  MartaAnna Szychlinska¹  Rosa Imbesi¹  Paola Castrogiovanni¹  Michelino Di Rosa¹  Giuseppe Musumeci¹  Claudia Guglielmino¹  Michele Vecchio²  Filippo Drago²  Alessandro Castorina³ 

[1] Department of Biomedical and Biotechnological Sciences, Human Anatomy and Histology Section, School of Medicine, University of Catania, Via S. Sofia n°87, 95124 Catania, Italy;Department of Biomedical and Biotechnological Sciences, Section of Pharmacology, University of Catania, via S. Sofia 67, 95123 Catania, Italy;School of Life Sciences, Faculty of Science, University of Technology Sydney, P.O. Box 123, Broadway, Sydney, NSW 2007, Australia;

关键词: osteoarthritis;    synovium;    physical activity;    interleukins;    lubricin;   

DOI  :  10.3390/ijms20030511

来源: DOAJ

【 摘 要 】

The purpose of this study was to investigate the influence of moderate physical activity (MPA) on the expression of osteoarthritis (OA)-related (IL-1β, IL-6, TNF-α, MMP-13) and anti-inflammatory and chondroprotective (IL-4, IL-10, lubricin) biomarkers in the synovium of an OA-induced rat model. A total of 32 rats were divided into four groups: Control rats (Group 1); rats performing MPA (Group 2); anterior cruciate ligament transection (ACLT)-rats with OA (Group 3); and, ACLT-rats performing MPA (Group 4). Analyses were performed using Hematoxylin & Eosin (H&E) staining, histomorphometry and immunohistochemistry. In Group 3, OA biomarkers were significantly increased, whereas, IL-4, IL-10, and lubricin were significantly lower than in the other experimental groups. We hypothesize that MPA might partake in rescuing type B synoviocyte dysfunction at the early stages of OA, delaying the progression of the disease.

【 授权许可】

Unknown