Dynamic Interleukin-6 Level Changes as a Prognostic Indicator in Patients With COVID-19

Frontiers in Pharmacology

Xiaohui Wu¹  Wen Zeng²  Liang Guo³  Zeming Liu³  Man Li³  Wei Long³  Jianglong Huang³  Yihui Huang³  Sichao Chen³  Danyang Chen³  Rongfen Gao⁴  Jinpeng Li⁵  Xinghuan Wang⁶ 

[1] Department of Neurosurgery, Zhongnan Hospital of Wuhan University, Wuhan, China;Department of Ophthalmology, Zhongnan Hospital of Wuhan University, Wuhan, China;Department of Plastic Surgery, Zhongnan Hospital of Wuhan University, Wuhan, China;Department of Rheumatology and Immunology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China;Department of Thyroid and Breast Surgery, Zhongnan Hospital of Wuhan University, Wuhan, China;Department of Urology, Zhongnan Hospital of Wuhan University, Wuhan, China;

关键词: COVID-19;    interleukin-6;    SARS-CoV-2;    CT scores;    infectious disease;    lung injury;   

DOI  :  10.3389/fphar.2020.01093

来源: DOAJ

【 摘 要 】

BackgroundInterleukin-6 (IL-6), a proinflammatory cytokine, has been reported to be associated with disease severity and mortality in patients with coronavirus disease 2019 (COVID-19). Yet, dynamic changes in IL-6 levels and their prognostic value as an indicator of lung injury in COVID-19 patients have not been fully elucidated.ObjectiveTo validate whether IL-6 levels are associated with disease severity and mortality and to investigate whether dynamic changes in IL-6 levels might be a predictive factor for lung injury in COVID-19 patients.MethodsThis retrospective, single-center study included 728 adult COVID-19 patients and used data extracted from electronic medical records for analyses.ResultsThe mortality rate was higher in the elevated IL-6 group than in the normal IL-6 group (0.16 vs 5%). Cox proportional hazards and logistic regression analyses for survival (adjusted hazard ratio, 10.39; 95% confidence interval [CI], 1.09–99.23; p = 0.042) and disease severity (adjusted odds ratio, 3.56; 95% CI, 2.06–6.19; p < 0.001) revealed similar trends. Curve-fitting analyses indicated that patient computed tomography (CT) scores peaked on days 22 and 24. An initial decline in IL-6 levels on day 16 was followed by resurgence to a peak, nearly in tandem with the CT scores.ConclusionIncreased IL-6 level may be an independent risk factor for disease severity and in-hospital mortality and dynamic IL-6 changes may serve as a potential predictor for lung injury in Chinese COVID-19 patients. These findings may guide future treatment of COVID-19 patients.

【 授权许可】

Unknown