Nelumbo nucifera leaf polyphenol extract inhibits breast cancer cells metastasis in vitro and in vivo through PKCα targeting

Journal of Functional Foods

Mon-Yuan Yang¹  Cheng-Hsun Wu²  Chau-Jong Wang³  Yi-Ju Lee⁴ 

[1] Department of Biochemistry, China Medical University, No. 91, Hsueh-Shih Road, Taichung 404, Taiwan;Department of Anatomy, China Medical University, No. 91, Hsueh-Shih Road, Taichung 404, Taiwan;Department of Pathology, Chung Shan Medical University Hospital, Taichung, Taiwan;Institute of Biochemistry, Microbiology and Immunology, Chung Shan Medical University, Taichung 40201, Taiwan;

关键词: Breast cancer;    Nelumbo nucifera leaf extract;    Nelumbo nucifera leaf polyphenol extract;    PKCα;    Migration;    MMP-9;   

DOI  :  

来源: DOAJ

【 摘 要 】

Nelumbo nucifera Gaertn. has long been used in food and traditional herbal medicine in Asia. It exhibits several biological properties including antitumor, antiangiogenic, antiobesity, and antioxidant properties. However, the active components and mechanisms underlying the effects of N. nucifera leaf extract (NLE) on breast tumor migration remain undefined. We found that NLE and N. nucifera leaf polyphenol extract (NLPE) significantly attenuated migration in MDA-MB-231 and 4T-1 breast cancer cells. The treatment of cells with NLE and NLPE suppressed the expression of RhoA, Rac1, and Cdc42. Furthermore, the activation of ERK and p38 MAPK was inhibited by NLE and NLPE. Notably, NLE and NLPE treatment significantly reduced the activation of protein kinase C α and the lung metastasis of breast cancer in vivo. Overall, our findings illustrate the roles of NLE and NLPE in breast cancer cell migration, suggesting that NLE and NLPE are potential chemopreventive agents for breast cancer metastasis.

【 授权许可】

Unknown