Kynurenine diminishes the ischemia-induced histological and electrophysiological deficits in the rat hippocampus

Neurobiology of Disease

Éva Rózsa¹  Katalin Sas²  József Toldi²  Hermina Robotka²  Zsolt Kis³  Márta Ágoston³  László Vécsei³  Tamás Farkas³  Gábor Gigler⁴  Gábor Szénási⁴  Máté Marosi⁴ 

[1] Department of Physiology, Anatomy and Neuroscience, University of Szeged, POB 533, H-6701 Szeged, Hungary;Department of Neurology, University of Szeged, POB 427, H-6701 Szeged, Hungary;Department of Physiology, Anatomy and Neuroscience, University of Szeged, POB 533, H-6701 Szeged, Hungary;Division of Preclinical Research, EGIS Pharmaceuticals PLC, Budapest, Hungary;

关键词: Ischemia;    Kynurenine;    Kynurenic acid;    Hippocampus;    CA1;    Neuroprotection;   

DOI  :  

来源: DOAJ

【 摘 要 】

The neuroprotective effect of l-kynurenine sulfate (KYN), a precursor of kynurenic acid (KYNA, a selective N-methyl-d-aspartate receptor antagonist), was studied. KYN (300 mg/kg i.p., applied daily for 5 days) appreciably decreased the number of injured pyramidal cells from 1850±100/mm2 to 1000±300/mm2 (p<0.001) in the CA1 region of the hippocampus in the four-vessel occlusion (4VO)-induced ischemic adult rat brain. A parallel increase in the number of intact, surviving neurons was demonstrated. Post-treatment with KYN (applied immediately right after reperfusion) proved to be much less effective. In parallel with the histology, a protective effect of KYN on the functioning of the CA1 region was observed: long-term potentiation was abolished in the 4VO animals, but its level and duration were restored by pretreatment with KYN. It is concluded that the administration of KYN elevates the KYNA concentration in the brain to neuroprotective levels, suggesting its potential clinical usefulness for the prevention of neuronal loss in neurodegenerative diseases.

【 授权许可】

Unknown