Epigenetic Regulatory Mechanisms Induced by Resveratrol

Nutrients

Diego Eidy Chiba¹  Chung Man Chin¹  Aline Renata Pavan¹  Jean Leandro Dos Santos¹  Guilherme Felipe Santos Fernandes¹  Gabriel Dalio Bernardes Silva¹ 

[1] School of Pharmaceutical Sciences, São Paulo State University (UNESP), 14800903 Araraquara, Brazil;

关键词: resveratrol;    epigenetic targets;    histone deacetylase;    SIRT1;    DNA methyltransferase;    histone acetyltransferase;   

DOI  :  10.3390/nu9111201

来源: DOAJ

【 摘 要 】

Resveratrol (RVT) is one of the main natural compounds studied worldwide due to its potential therapeutic use in the treatment of many diseases, including cancer, diabetes, cardiovascular diseases, neurodegenerative diseases and metabolic disorders. Nevertheless, the mechanism of action of RVT in all of these conditions is not completely understood, as it can modify not only biochemical pathways but also epigenetic mechanisms. In this paper, we analyze the biological activities exhibited by RVT with a focus on the epigenetic mechanisms, especially those related to DNA methyltransferase (DNMT), histone deacetylase (HDAC) and lysine-specific demethylase-1 (LSD1).

【 授权许可】

Unknown