A New Class of Smart Gadolinium Contrast Agent for Tissue pH Probing Using Magnetic Resonance Imaging

Molecules

Mohammed Zourob¹  Ali A. Husain²  Fouzi Mouffouk²  Mozhdeh Seyyedhamzeh²  Abdullah Alhendal²  Hacene Serrai³  Sourav Bhaduri³  Rik Achten³ 

[1] Department of Chemistry, Alfaisal University, 12713 Riyadh, Saudi Arabia;Department of Chemistry, Kuwait University, P.O. Box 5969, Safat 13060, Kuwait;Department of Diagnostic Sciences, University of Ghent, Gent 9000, Belgium;

关键词: cancer imaging;    mri;    ph;    sensors;   

DOI  :  10.3390/molecules25071513

来源: DOAJ

【 摘 要 】

: Detecting tissue pH in vivo is extremely vital for medical diagnosis and formulation of treatment decisions. To this end, many investigations have been carried out to develop an accurate and efficient method of in vivo pH measurement. Most of the techniques developed so far suffer from inadequate accuracy, due to poor sensitivity at low concentration of the target or nonspecific interactions within the tissue matrix. To overcome these issues, we describe herein the development of a simple, yet reliable, way to estimate pH with high precision using a Gd(III)-DOTA-silyl-based acid-labile group as a pH-sensitive contrast agent with Magnetic Resonance Imaging (MRI). With this method, a change in T1 weighted image intensity of the newly developed pH-sensitive contrast is directly linked to the proton concentration in the media. As a result, we were able estimate the pH of the target with 95% reliability.

【 授权许可】

Unknown