NaHSO4-SiO2: An Efficient Reusable Green Catalyst for Selective C-3 Propargylation of Indoles with Tertiary Propargylic Alcohols

Iranian Journal of Chemistry & Chemical Engineering

Barend C.B. Benzuidenhoudt¹  Mukut Gohani¹  Johannes H. van Tonder¹ 

[1] Department of Chemistry, University of the Free State, P.O. Box 339, Bloemfontein 9300, SOUTH AFRICA;

关键词: alkylation;    catalyst;    indole;    propargylic alcohols;    sodium bisulfate-silica;   

DOI  :  

来源: DOAJ

【 摘 要 】

Although several methods for the preparation of 4o propargyl indole derivatives have been published, this synthetic transformation is complicated by the tendency of 3o propargyl alcohols to form allenium intermediates in acidic media.  It is therefore a challenge to find an efficient method for the C-3 propargylation of indoles with 3° propargylic alcohols.  In this paper we wish to report on the successful application of silica gel impregnated with NaHSO4 as catalyst for the preparation of 4o propargyl indole derivatives.

【 授权许可】

Unknown