Catalytic synthesis and antimicrobial activity of N-(3-chloro-2-oxo-4-phenylazetidin-1-yl)-4-(1H-indol-3-yl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxamides

Heterocyclic communications

article

Nisheeth C. Desai¹  Malay J. Bhatt¹ 

[1] Department of Chemistry (DST-FIST Sponsored and UGC NON-SAP), Mahatma Gandhi Campus, Maharaja Krishnakumarsinhji Bhavnagar University

关键词: antimicrobial;    2-azetidinone;    catalyst;    indole;    β-lactam;    MIC;    1;    2;    3;    4-tetrahydropyrimidine;   

DOI  :  10.1515/hc-2016-0032

学科分类：内科医学

来源: De Gruyter

【 摘 要 】

In continuation of our work towards synthesizing bio-active molecules we developed and optimized the methodology for novel N -(3-chloro-2-oxo-4-phenylazetidin-1-yl)-4-(1 H -indol-3-yl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide analogues from readily available starting materials. We focused on the pressing demand to find eco-friendly pathways by means of catalytic optimization of the process. All synthesized compounds were screened for in vitro antibacterial and antifungal activities on Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, Staphylococcus pyogenes, Candida albicans, Aspergillus niger , and Aspergillus clavatus species.

【 授权许可】

CC BY|CC BY-NC-ND