1H NMR-based metabonomics of the protective effect of Curcuma longa and curcumin on cinnabar-induced hepatotoxicity and nephrotoxicity in rats

Journal of Functional Foods

Gang Chen¹  Guangyue Su²  Jiao Bai³  Yuehu Pei³  Haifeng Wang³ 

[1] Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China;;Key Laboratory of Structure-Based Drug Design &Department of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China;

关键词: Metabonomics;    NMR;    Curcuma longa;    Curcumin;   

DOI  :  

来源: DOAJ

【 摘 要 】

Curcuma longa is a perennial herb that is widely cultivated extensively in Asia and Africa. Curcumin is a major constituent of C. longa. A metabonomics approach based on high-resolution 1H nuclear magnetic resonance spectroscopy was applied to investigate the toxicity protective effects of C. longa and curcumin in rats under cinnabar induced hepatotoxicity and nephrotoxicity. Partial least squares-discriminant analysis (PLS-DA) was performed to identify different metabolic profiles of urine and serum from rats. Liver and kidney histopathology examinations and serum clinical chemistry analysis were also performed. The significant difference in metabolic profiling of urine and serum of the rats was observed among cinnabar treated group, control group, co administration of C. longa and cinnabar, co administration of curcumin and cinnabar group. The results suggested that C. longa and curcumin have the effective protection function through regulating the energy metabolism, intestinal microflora and amino acid metabolism to the liver and kidney injury induced by cinnabar.

【 授权许可】

Unknown