Effect of individualized therapy for AIDS patients with cytomegalovirus retinitis in intravitreal ganciclovir injections

International Journal of Ophthalmology

Wen-Bin Wei¹  Hong-Wei Dong²  Kui-Fang Du²  Chun-Gang Guo²  Chao Chen²  Lian-Yong Xie²  Wen-Jun Kong² 

[1] Beijing Tongren Eye Center, Beijing Key Laboratory of Intraocular Tumor Diagnosis and Treatment, Beijing Ophthalmology &Beijing YouAn Hospital, Capital Medical University, Beijing 100069, China;

关键词: cytomegalovirus;    retinitis;    acquired immune deficiency syndrome;    ganciclovir;    intravitreal injection;    monotherapy;   

DOI  :  10.18240/ijo.2019.08.19

来源: DOAJ

【 摘 要 】

The effect of intravitreal ganciclovir injection combined with intravenous infusion on acquired immune deficiency syndrome (AIDS) patients with cytomegalovirus retinitis (CMVR) was investigated. A total of 32 eyes in 23 AIDS patients diagnosed as CMVR from 2017 to 2018 were included in the retrospective study. All patients underwent induction therapy by using intravenous drip of the anti-cytomegalovirus (CMV) agent ganciclovir (5 mg/kg q12h) combined with intravitreal ganciclovir injection (3 mg/time, 2 times/wk). The visual acuity, fundus photographs, lesion location, and number of intravitreal injections were observed preoperatively and postoperatively. Totally 14 eyes were cured during induction therapy. The number of injections [4.13 (2 to 6)] in CMVR patients with peripherally fundus lesions were significantly lower than those with central lesions [4.89 (2 to 6)]. The individualized therapy of intravitreal ganciclovir injections for AIDS patients with CMVR can effectively reduce the numbers of intravitreal injections.

【 授权许可】

Unknown