Cytomegalovirus Retinitis in Three Pediatric Cases with Acute Lymphoblastic Leukemia: Case Series and Review of the Literature

Japanese Journal of Infectious Diseases

Ayşe Karaaslan¹  Gülşen Akkoç¹  Ahmet Soysal¹  Nurhayat Yakut¹  Haluk Kazokoğlu²  Ahmet Koç³  Eda Kepenekli Kadayifci¹  Sevliya Öcal Demir¹  Mustafa Bakır¹  Emel Şenay³  Hande Çeliker²  Serkan Atıcı¹ 

[1] Division of Pediatric Infectious Diseases, Marmara University School of Medicine;Department of Ophthalmology, Marmara University School of Medicine;Division of Pediatric Hematology and Oncology, Department of Pediatrics, Marmara University School of Medicine

关键词: cytomegalovirus;    retinitis;    ganciclovir;    leukemia;   

DOI  :  10.7883/yoken.JJID.2015.223

学科分类：传染病学

来源: National Institute of Infectious Diseases

【 摘 要 】

References(14)Cytomegalovirus (CMV) retinitis is typically diagnosed in patient with AIDS and those who underwent allogeneic hematopoietic cell transplant. However, it may develop in patients with acute lymphoblastic leukemia (ALL) who have not undergone hematopoietic cell transplantation. To increase awareness of CMV retinitis in this group, we describe 3 patients ages 3, 9, and 12, with ALL who developed CMV retinitis. The diagnosis of CMV retinitis was made on the basis of ophthalmological findings suggesting typical retinal lesions. In 2 cases, CMV DNAemia was present, while in 1 patient CMV DNA was detected only in vitreous fluid using the PCR technique. All cases were treated with intravenous ganciclovir for 2 or 3 weeks as induction therapy, followed by oral valganciclovir prophylaxis. Initially, active retinitis lesions resolved in all cases; however, in 1 patient CMV retinitis relapsed 3 times during follow-up. In this case, by using foscarnet therapy, satisfactory responses were achieved and the progression of CMV retinitis lesions stopped and eventually regressed.

【 授权许可】

Unknown