Prognostic and Therapeutic Value of Apolipoprotein A and a New Risk Scoring System Based on Apolipoprotein A and Adenosine Deaminase in Chronic Lymphocytic Leukemia

Frontiers in Oncology

Xin Wang⁴  Zixun Yin⁴  Ming Liu⁴  Huimin Zhang⁴  Ya Zhang⁴  Xin Zhang⁴  Xiang Sun⁴  Xiaoya Yun⁴  Xinting Hu⁴ 

[1] Branch of National Clinical Research Center for Hematologic Diseases, Jinan, China;Department of Hematology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China;Department of Hematology, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China;National Clinical Research Center for Hematologic Diseases, The First Affiliated Hospital of Soochow University, Suzhou, China;School of Medicine, Shandong University, Jinan, China;Shandong Provincial Engineering Research Center of Lymphoma, Jinan, China;

关键词: chronic lymphocytic leukemia (CLL);    apolipoprotein A;    prognosis;    L-4F;    lipid metabolism;   

DOI  :  10.3389/fonc.2021.698572

来源: DOAJ

【 摘 要 】

Lipid metabolism is related to lymphomagenesis, and is a novel therapeutic target in some hematologic tumors. Apolipoprotein A (ApoA), the major protein of high-density lipoprotein (HDL), plays a crucial role in lipid transportation and protecting against cardiovascular disease, and takes effect on anti-inflammation and anti-oxidation. It is correlated with the prognosis of some solid tumors. Yet, there is no investigation involving the role of ApoA plays in chronic lymphocytic leukemia (CLL). Our retrospective study focuses on the prognostic value of ApoA in CLL and its therapeutic potential for CLL patients. Herein, ApoA is a favorable independent prognostic factor for both overall survival (OS) and progression-free survival (PFS) of CLL patients. ApoA is negatively associated with β2-microglobulin (β2-MG) and advanced stage, which are poor prognostic factors in CLL. Age, Rai stage, ApoA, and adenosine deaminase (ADA) are included in a new risk scoring system named ARAA-score. It is capable of assessing OS and PFS of CLL patients. Furthermore, cell proliferation assays show that the ApoA-I mimetic L-4F can inhibit the proliferation of CLL cell lines and primary cells. In conclusion, ApoA is of prognostic value in CLL, and is a potential therapy for CLL patients. The ARAA-score may optimize the risk stratification of CLL patients.

【 授权许可】

Unknown