Th17-Dependent Nasal Hyperresponsiveness Is Mitigated by Steroid Treatment

Biomolecules

Akio Mori¹  Kento Miura²  Hideki Kawasaki²  Sawako Ogata²  Shusaku Ueda²  Norimasa Yamasaki²  Shuka Miura²  Osamu Kaminuma² 

[1] Clinical Research Center for Allergy and Rheumatology, National Hospital Organization, Sagamihara National Hospital, Kanagawa 252-0392, Japan;Department of Disease Model, Research Institute of Radiation Biology and Medicine, Hiroshima University, Hiroshima 734-8553, Japan;

关键词: inflammation;    nasal hyperresponsiveness;    Th17 cell;    dexamethasone;    mouse;   

DOI  :  10.3390/biom12050674

来源: DOAJ

【 摘 要 】

Th17 cells are implicated in allergic inflammatory diseases, including allergic rhinitis (AR), though the effect of steroids on Th17 cell-dependent nasal responses is unclear. Herein, we investigated a nasal inflammation model elicited by allergen provocation in mice infused with Th17 cells and its responsiveness against steroid treatment. We transferred BALB/c mice with Th17 cells, which were differentiated in vitro and showed a specific reaction to ovalbumin (OVA). We challenged the transferred mice by intranasal injection of OVA and to some of them, administered dexamethasone (Dex) subcutaneously in advance. Then, we assessed immediate nasal response (INR), nasal hyperresponsiveness (NHR), and inflammatory cell infiltration into the nasal mucosa. The significant nasal inflammatory responses with massive neutrophil accumulation, INR, and NHR were induced upon allergen challenge. Allergen-induced INR and NHR were significantly suppressed by Dex treatment. This study suggested the effectiveness of steroids on Th17 cell-mediated nasal responses in AR.

【 授权许可】

Unknown