The Role of Gamma-Delta T Cells in Diseases of the Central Nervous System

Frontiers in Immunology

Zhizhong Li¹  Guodong Sun¹  Jin Wo¹  Wencai Zhang¹  Feng Zhang²  Chenghong Sun³ 

[1] Department of Orthopedics, First Affiliated Hospital, Jinan University, Guangzhou, China;Intensive Care Unit, First Affiliated Hospital, Jinan University, Guangzhou, China;State Key Laboratory of Generic Manufacture Technology of Chinese Traditional Medicine, Linyi, China;

关键词: γδ T cell;    Th17 cell;    cytokines;    inflammation;    central nervous system;    IL-17;   

DOI  :  10.3389/fimmu.2020.580304

来源: DOAJ

【 摘 要 】

Gamma-delta (γδ) T cells are a subset of T cells that promote the inflammatory responses of lymphoid and myeloid lineages, and are especially vital to the initial inflammatory and immune responses. Given the capability to connect crux inflammations of adaptive and innate immunity, γδ T cells are responsive to multiple molecular cues and can acquire the capacity to induce various cytokines, such as GM-CSF, IL-4, IL-17, IL-21, IL-22, and IFN-γ. Nevertheless, the exact mechanisms responsible for γδ T cell proinflammatory functions remain poorly understood, particularly in the context of the central nervous system (CNS) diseases. CNS disease, usually leading to irreversible cognitive and physical disability, is becoming a worldwide public health problem. Here, we offer a review of the neuro-inflammatory and immune functions of γδ T cells, intending to understand their roles in CNS diseases, which may be crucial for the development of novel clinical applications.

【 授权许可】

Unknown