iScience | |
Sensor array and gas chromatographic detection of the blood serum volatolomic signature of COVID-19 | |
Corrado Di Natale1  Lorena Di Zazzo2  Roberto Paolesse2  Yolande Ketchanji Mougang3  Rosamaria Capuano3  Alexandro Catini3  Marilena Minieri4  Sergio Bernardini4  Jacopo Maria Legramante5  | |
[1] Emerging Technologies Division of International Federation Clinical Chemistry and Laboratory Medicine (IFCC), Milano, Italy;Department of Chemical Science and Technology, University of Rome Tor Vergata, Via della Ricerca Scientifica, 00133 Rome, Italy;Department of Electronic Engineering, University of Rome Tor Vergata, Via del Politecnico 1, 00133 Rome, Italy;Department of Experimental Medicine, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy;Department of Medicine's Systems, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy; | |
关键词: Health sciences; Diagnostics; Biotechnology; Medical biotechnology; | |
DOI : | |
来源: DOAJ |
【 摘 要 】
Summary: Volatolomics is gaining consideration as a viable approach to diagnose several diseases, and it also shows promising results to discriminate COVID-19 patients via breath analysis. This paper extends the study of the relationship between volatile compounds (VOCs) and COVID-19 to blood serum. Blood samples were collected from subjects recruited at the emergency department of a large public hospital. The VOCs were analyzed with a gas chromatography mass spectrometer (GC/MS). GC/MS data show that in more than 100 different VOCs, the pattern of abundances of 17 compounds identifies COVID-19 from non-COVID with an accuracy of 89% (sensitivity 94% and specificity 83%). GC/MS analysis was complemented by an array of gas sensors whose data achieved an accuracy of 89% (sensitivity 94% and specificity 80%).
【 授权许可】
Unknown