Sensor array and gas chromatographic detection of the blood serum volatolomic signature of COVID-19

iScience

Corrado Di Natale¹  Lorena Di Zazzo²  Roberto Paolesse²  Yolande Ketchanji Mougang³  Rosamaria Capuano³  Alexandro Catini³  Marilena Minieri⁴  Sergio Bernardini⁴  Jacopo Maria Legramante⁵ 

[1] Emerging Technologies Division of International Federation Clinical Chemistry and Laboratory Medicine (IFCC), Milano, Italy;Department of Chemical Science and Technology, University of Rome Tor Vergata, Via della Ricerca Scientifica, 00133 Rome, Italy;Department of Electronic Engineering, University of Rome Tor Vergata, Via del Politecnico 1, 00133 Rome, Italy;Department of Experimental Medicine, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy;Department of Medicine's Systems, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy;

关键词: Health sciences;    Diagnostics;    Biotechnology;    Medical biotechnology;   

DOI  :  

来源: DOAJ

【 摘 要 】

Summary: Volatolomics is gaining consideration as a viable approach to diagnose several diseases, and it also shows promising results to discriminate COVID-19 patients via breath analysis. This paper extends the study of the relationship between volatile compounds (VOCs) and COVID-19 to blood serum. Blood samples were collected from subjects recruited at the emergency department of a large public hospital. The VOCs were analyzed with a gas chromatography mass spectrometer (GC/MS). GC/MS data show that in more than 100 different VOCs, the pattern of abundances of 17 compounds identifies COVID-19 from non-COVID with an accuracy of 89% (sensitivity 94% and specificity 83%). GC/MS analysis was complemented by an array of gas sensors whose data achieved an accuracy of 89% (sensitivity 94% and specificity 80%).

【 授权许可】

Unknown