Immunological activities of polysaccharide extracted from Elaeagnus angustifolia L.

CyTA - Journal of Food

Xu-hui Liu¹  Na-xin Sun¹  Xiao-qing Liu¹  Xiang-xin Xu¹  Wen-tan Tian¹  Yan Zhang¹  Shu Wang¹  Hui-ping Liu¹ 

[1] Tianjin University of Science & Technology;

关键词: Elaeagnus angustifolia L.;    polysaccharide;    immunological activity;   

DOI  :  10.1080/19476337.2018.1516240

来源: DOAJ

【 摘 要 】

The study was to investigate the immunological activities of polysaccharide isolated from Elaeagnus angustifolia L. The extracted Elaeagnus angustifolia L. polysaccharide (EAP) was purified by DEAE cellulose-52 chromatography (DEAE-52) and Sephadex G-100 size-exclusion chromatography (G-100). Then the average molecular weight (Mw) of purified polysaccharide was determined by high-performance gel permeation chromatography (HPGPC). One main fraction (EAP-1a) was obtained through the isolation and purification steps. The results showed that EAP-1a had strong immunological activities. EAP-1a could significantly increase spleen and thymus index, enhance the NK cell activity, stimulate the phagocytosis of peritoneal phagocyte and increase the level of IL-2, IFN-γ and IgG in serum. Thus, EAP-1a isolated from Elaeagnus angustifolia L. could enhance the immunological activities of immunosuppressed mice induced by cyclophosphamide (CY).

【 授权许可】

Unknown