Emerging Role of Eukaryote Ribosomes in Translational Control

International Journal of Molecular Sciences

Nicole Dalla Venezia¹  Anne Vincent¹  Frédéric Catez¹  Virginie Marcel¹  Jean-Jacques Diaz¹ 

[1] Univ Lyon, Université Claude Bernard Lyon 1, Inserm U1052, CNRS UMR5286, Centre Léon Bérard, Centre de Recherche en Cancérologie de Lyon, 69008 Lyon, France;

关键词: specialized ribosome;    ribosome composition;    rRNA modification;    ribosomal protein;    translational regulation;   

DOI  :  10.3390/ijms20051226

来源: DOAJ

【 摘 要 】

Translation is one of the final steps that regulate gene expression. The ribosome is the effector of translation through to its role in mRNA decoding and protein synthesis. Many mechanisms have been extensively described accounting for translational regulation. However it emerged only recently that ribosomes themselves could contribute to this regulation. Indeed, though it is well-known that the translational efficiency of the cell is linked to ribosome abundance, studies recently demonstrated that the composition of the ribosome could alter translation of specific mRNAs. Evidences suggest that according to the status, environment, development, or pathological conditions, cells produce different populations of ribosomes which differ in their ribosomal protein and/or RNA composition. Those observations gave rise to the concept of “specialized ribosomes”, which proposes that a unique ribosome composition determines the translational activity of this ribosome. The current review will present how technological advances have participated in the emergence of this concept, and to which extent the literature sustains this concept today.

【 授权许可】

Unknown