Metabolomics approach to identify the active substances influencing the antidiabetic activity of Lagerstroemia species

Journal of Functional Foods

Jin-Hyub Paik¹  Kongmany Sydara¹  Adek Nizar¹  Su Ui Lee¹  Hyun-Jae Jang¹  Sei-Ryang Oh²  Hyung Won Ryu³  Hang Jin⁴  So-Yeun Woo⁴  Jae-Won Lee⁵  Tran The Bach⁶  Eun-Bin Kwon⁶  Mun-Ock Kim⁶  SangHo Choi⁶  Heung Joo Yuk⁶ 

[1] Biotechnology (KRIBB), Cheongju 28116, Republic of Korea;Center for Pharmaceutical and Medical Technology, Deputy for Agroindustrial Technology and Biotechnology, The Agency for the Assessment and Application of Technology (BPPT), Jl. M.H. Thamrin No. 8, Jakarta 10340, Indonesia;Institute of Ecology and Biological Resources, Vietnam Academy of Science and Technology (VAST). 18 Hoang Quoc Viet, Cau Giay, Ha Noi, Viet Nam;International Biological Material Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon, Yuseong-gu, Daejeon 34141, Republic of Korea;Korean Medicine Convergence Research Division, Korea Institute of Oriental Medicine (KIOM), Daejeon 34054, Republic of Korea;;Natural Medicine Research Center, Korea Research Institute of Bioscience &

关键词: Lagerstroemia;    Metabolomics;    Flavonol glycosides;    Corosolic acid;    Antidiabetic;   

DOI  :  

来源: DOAJ

【 摘 要 】

Rational and efficient approaches to research and development are becoming more popular for increasing value enhancement in bioactive materials. In this study, metabolite profiles of 17 different Lagerstroemia species from different countries were performed using UPLC-QTof-MS combined with chemometric tools to identify potential metabolite predictors of antidiabetic activity. PLS-DA of the Lagerstroemia samples indicated two large, distinct clusters in the score plot. On the loading scatter plot, significant changes in metabolites of antidiabetic candidates were found between species, and two flavonol glycosides and corosolic acid were evaluated as key markers among the 25 analyzed metabolites. Based on the screening results, samples high in two triterpenic acids (corosolic acid and asiatic acid) showed a tendency to inhibit glucose uptake, which could have contributed to the correlation of active and inactive extracts. Therefore, these comprehensive results support our biochemometric models and contribute to the rational and efficient studies of pharmacologically active metabolites.

【 授权许可】

Unknown