Considerations and challenges for sex-aware drug repurposing

Biology of Sex Differences

Elizabeth J. Ramsey¹  Avery S. Williams¹  Victoria L. Flanary¹  Emma F. Jones¹  Brittany N. Lasseigne¹  Jennifer L. Fisher¹ 

[1] Department of Cell, Developmental and Integrative Biology, Heersink School of Medicine, University of Alabama at Birmingham;

关键词: Sex differences;    Drug repurposing;    Sex-bias;    Sex-aware;    Review;    Therapeutics;   

DOI  :  10.1186/s13293-022-00420-8

来源: DOAJ

【 摘 要 】

Highlights Genetic, epigenetic, hormonal, immunological, metabolic, and environmental factors affect sex-biased drug responses. Drug repurposing approaches provide a significant advantage over novel drug development by reducing lengthy and costly clinical trials. Advances in compute processing power and optimized algorithms for computational systems have increased the efficiency and feasibility of computational drug repurposing. Multiple challenges still need to be addressed for sex-aware drug repurposing, including the insufficient understanding of the cause of variation of drug responses due to sex differences, better performing sex-aware repurposing methods, and the lack of large and balanced datasets to develop improved methods. Future low-dimensional representations of molecular association and network approaches could significantly impact the field of sex-aware drug repurposing.

【 授权许可】

Unknown