Pancreas Bone Testis Axis

Arsiv Kaynak Tarama Dergisi

Hulya Ozgur¹  Sait Polat¹  Gulfidan Coskun² 

[1] CUKUROVA UNiVERSiTESi, TIP FAKULTESi, TIBBi HiSTOLOJi VE EMBRiYOLOJi ANABiLiM DALI, SARICAM-ADANA;CUKUROVA UNiVERSiTESi, TIP FAKULTESi, TIBBi HiSTOLOJi VE EMBRiYOLOJi ANABiLiM DALI, SARICAM-ADANA;

关键词: Pancreas;    Bone;    Testis;    Insulin;    Osteocalcin;    Testosterone;   

DOI  :  

来源: DOAJ

【 摘 要 】

Bone which has movement and support functions, is the largest organ of the body. Bone is regulated by hormonal signal butit also acts as an endocrine organ. Many peptide hormones such as osteocalcin are secreted from bone. Osteocalcin which is an osteoblast derived hormone, has two forms:and ldquo;carboxylated (inactive) osteocalcin and decarboxylated (active) osteocalcin and rdquo;. While inactive osteocalcin is found in bone matrix, active osteocalcin is given to blood circulation and acts as a multifunctional hormone. In the past ten years, numerous epidemiological, genetic and biochemical studies have revealed hormonal links between bone and pancreas, adipose tissue, gonads via active osteocalcin. In this review, a newly defined pathway called pancreas-bone-testis axis which stimulates testosterone synthesis independent of hypothalamic hypophyseal testicular axis, is discussed. [Archives Medical Review Journal 2015; 24(3.000): 355-367]

【 授权许可】

Unknown